Plymouth's Woodside Animal Sanctuary found homes for 1,256 animals in 2014 the charity has revealed.
The Elfordleigh sanctuary said they continue to see a huge demand for their services in rehoming animals, assistance in neutering and work in the community for the welfare of animals.
Carole Bowles MBE said: "I am still left gobsmacked on many occasions by the wonderful support we receive.
"It is an amazing number of animals to have placed in new homes.
"But our goal would be to home less as the years go by, in the hope that breeding is taken much more seriously and pets are taken on with the great deal of thought that it deserves".
Woodside hopes 2015 will be even better, as it continues to try to educate and its work within the community.
Carole said: "There are so many ways people can support us, financially, through donating items on our shopping lists or amazon wishlist, adopting rather than going to a breeder or pet shop, educating themselves and others on the best animal welfare, donating to our charity shops. The list goes on.
"Please, we ask even if you can do just one thing in 2015 to help either the animals in our care or animals in the area in general, then please do it."